Peristaltic pumps, with their gentle delivery, low shear, and high cleanliness characteristics, are used throughout the entire production process.
1.In upstream culture processes, peristaltic pumps are commonly used for the transfer of cell culture media, buffers, and feed additives. Especially in batch feeding, they allow for precise control of the feed rate, enabling metabolic control and yield optimization. Peristaltic pumps also play a crucial role in critical operations such as aseptic inoculation and pH adjustment agent addition.
2. In the midstream separation and concentration stages, peristaltic pumps are widely used in membrane filtration systems, including ultrafiltration, microfiltration, and nanofiltration. Their stable flow rate control helps improve membrane flux, extend membrane lifetime, and reduce shear damage to sensitive biomolecules such as proteins or viruses.
3.In downstream filling stages, peristaltic pumps can be integrated with filling systems to achieve high-precision quantitative filling from milliliters to liters, suitable for end-product dosage forms such as vaccines, recombinant proteins, monoclonal antibodies, and cell therapy products. When used in conjunction with a weighing feedback or flow closed-loop control system, it enables automatic calibration and error compensation, significantly improving filling consistency and accuracy.
4.In quality control and process monitoring, peristaltic pumps are commonly used in aseptic sampling and online analysis modules, such as in conjunction with pH, conductivity, and optical density sensors for online PAT monitoring. This avoids contamination and sample loss, ensuring the representativeness and reliability of the data.