1.Background
With the rapid development of biopharmaceutical technology, the industry has placed increasingly stringent demands on the cleanliness, controllability, flexibility, and automation of production processes. In complex bioreaction and separation/purification processes, stable fluid transfer is crucial for ensuring product quality, improving production efficiency, and complying with GMP and other regulatory standards.
2.Peristaltic pumps, as high-cleanliness, low-shear, cross-contamination-free, easy-to-operate, and easy-to-maintain volumetric delivery devices, are widely used in biopharmaceutical processes due to their unique working principle and structural advantages. These applications cover multiple stages, from upstream cell culture and culture medium feeding, midstream separation and filtration, downstream filling, to process sampling and online monitoring.
3.A key feature of peristaltic pumps in biopharmaceutical applications is that the fluid only contacts the inner wall of the pump tubing throughout the entire process, avoiding contact with the pump body or other mechanical components. This contactless transfer structure significantly reduces the risk of contamination, making it particularly suitable for biopharmaceutical environments with extremely high sterility and cleanliness requirements. Furthermore, the pump tubing can be quickly replaced or uses disposable components, greatly simplifying the equipment cleaning and validation process.